Febrile response in CNS is mediated by all except

Fever is produced in response to substances called pyrogens that act by stimulating prostaglandin synthesis in the vascular and perivascular cells of hypothalamus. They can be classified as: Exogenous pyrogens - Endotoxin of gram ‘-’ bacteria, superantigens (gram ‘+’ bacteria). Endogenous pyrogens - IL-1, TNF-alpha, Ciliary neurotropic factor and IFN-alpha. PGE 2 is the most important chemical responsible for elevation of hypothalamic set point in the body. So, NSAIDs reduce fever by inhibiting cyclooxygenase and reducing prostaglandin concentration.