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Pharmacology General Pharmacology a9325f41

Time required to reach the steady state after a dosage regimen depends on:

A
Route of administration
B
Half life of a drug
C
Dosage interval
D
Dose of drug
High-Yield Explanation
Ans. (B) Half life of a drug(Ref: KDT 8th/e p40-41)* After a dosage regimen, concentration of the drug to reach the steady state (when the elimination balances the input) is called steady state plasma concentration Cpss.* Cpss is reached in about 4-5 half lives.* The amplitude of fluctuations in Cpss depends on the dose interval relative to t1/2 .

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