Pharmacology Other topics and Adverse effects a91fdf88

With respect to ticlopidine, clopidogrei:

Is more likely to cause formation of antiplatelet antibodies

15 less likely to cause neutropenia

Is more likely to cause severe bleeding

Has a greater antiplatelet effect

High-Yield Explanation

(Ref: KDT 6/e p610) Ticlopidine and clopidogrel are ADP antagonists and are used as antiplatelet drugs. Antiplatelet action, chances of bleeding and formation of antibodies is similar with these two agents. Clopidogrel is better tolerated because it is less likely to cause severe neutropenia and thrombocy topenia as compared to ticlopidine.

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