In treatment of Parkinsonism with Levodopa dose limiting toxicity is

(B) Vomitings # ADVERSE EFFECTS 2# HAEMATOLOGICAL Dose limiting toxicity> Leucopenia, nadir 21 - 28 days, recovery 28 - 35 days.> Thrombocytopenia, nadir 16 days, recovery 21 days.# GASTROINTESTINAL Dose limiting toxicity> Severe nausea and vomiting, duration 1-12 hours. Aggressive antiemetic prophylaxis is recommended.> Nausea is most severe on the first day of multiple day treatment.# LOCAL REACTIONS> Severe pain at injection site and along vein during administration. Slow infusion rate, and place an ice pack above the injection site. Further dilution of solution may be required.# MISCELLANEOUS> Hypotension, with single doses of 850 mg/m2 or greater.> Elevated liver function tests, venous occlusive disease, acute liver dystrophy with fatal thrombosis.> Increased blood urea and serum creatinine.> Reversible alopecia, facial paraesthesia, facial flushing.> Flu-like symptoms e.g. fever, myalgia, and malaise may occur, especially after large, single doses. Onset 7 days, duration 7-21 days.