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Gynaecology & Obstetrics Abortion a8ef27ca

MC genetic cause of spontaneous abortion is:

A
Triplody
B
Monosomy
C
Trisomy
D
Single gene deletion
High-Yield Explanation
Ans. is 'c' i.e., Trisomy * Abortion occurring without medical or mechanical means to empty the uterus is referred to as spontaneous.* More than 80% of abortions occur in the first 12 weeks of pregnancy, and at least half result from chromosomal anomalies.* After the first trimester, both the abortion rate and the incidence of chromosomal anomalies decrease.* Trisomy 16 is the most common abnormal karyotype found in the abortus.* Monosomy X (45 X), the second most frequent chromosomal abnormality (after trisomy), usually results in abortion and much less frequently in live born female infants (Turner syndrome).* Trisomies have been identified in abortus for all except chromosome 1.

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