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Unknown General a8b90037

All are true regarding chloroquine, EXCEPT :

A
Acts only on exo erythrocytic cycle
B
Acts on DNA and RNA of parasite
C
Causes pigmentation of nail and mucosa
D
Infected RBC has more drug
High-Yield Explanation
Ans. is 'a' acts only on exoerythrocytic cycle.]Reference KDT 5th p. 739 (4th page 793)]Chloroquine is a rapidly acting erythrocytic schizonticide. It is active against all species of plasmodium.It has no effect on pre and exoerythrocytic phase of the parasite.Mechanism of action of chloroquine :|First chloroquine is concentrated inside infected erythrocytes. (Higher cone in infected RBC).|Prevents the polymerization of heme into hemozoin|Heme damages the plasmodium membrane.About choice "B" K.D.T. says -" The earlier hypothesis that chloroquine acts by interfering with DNA function is now considered untenable"

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