Risk factors associated with the development of Gout all except
High-Yield Explanation
Gout is an inflammatory disease caused by deposition of monosodium urate monohydrate crystals in and around synovial joints.
Causes of hyperuricaemia and gout
Diminished renal excretion
Increased renal tubular reabsorption*
Renal failure
Lead toxicity
Lactic acidosis
Alcohol
Drugs-Thiazide and loop diuretics, Low-dose aspirin, Ciclosporin, Pyrazinamide
Increased intake
Red meat
Seafood
Offal
Over-production of uric acid
Myeloproliferative and lymphoproliferative disease
Psoriasis
High fructose intake
Glycogen storage disease
Inherited disorders
Lesch–Nyhan syndrome (HPRT mutations)
Phosphoribosyl pyrophosphate synthetase 1 mutation