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Biochemistry Fuel in Fed, Fasting and Starvation a8979ec8

Increased formation of ketone bodies during fasting is a result of:

A
Decreased level of circulating glucagon
B
Decreased formation of Acetyl CoA in the liver
C
Increased levels of free fatty acids in blood
D
Inhibition of b-oxidation of fatty acids in liver
High-Yield Explanation
Free fatty acids bound to albumin are increased as a result of an increased activity of Hormone sensitive lipase in adipose tissue as this enzyme breaks TG into glycerol & fatty acids. These fatty acids are taken up by liver. b-oxidation of these fatty acids in liver provides the acetyl CoA for ketogenesis. Hepatic ketogenesis is also stimulated by elevated levels of glucagon during fasting.

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