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Medicine General a8859d54

Anticentromere antibodies are most commonly associated with :

A
Diffuse cutaneous systemic sclerosis
B
Mixed connective tissue disease
C
CREST syndrome
D
Polymyositis
High-Yield Explanation
Answer is C (CREST syndrome): Anticentromere antibodies are characteristic of CREST syndrome. Anticentromere antibodies are present in 40 - 80% of patients with limited cutaneous scleroderma or crest syndrome. Anticentromere antibodies are found in only about 2% to 5% of patients with diffuse cutaneous scleroderma, and rarely in other connective tissue disease.-

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