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Pharmacology Cardiovascular system a870fe92

Which of the following statement is true about nitrates

A
Acts by raising CGMP which causes dephosphorylation of MLCK
B
Metabolized by glutathione reductase
C
Used in achlasia cardia
D
All of the above
High-Yield Explanation
Nitrates acts by releasing nitric oxide which increases cGMP that cause dephosphorylation of myosin light chain kinase. These are preferential dilators of venules because glutathione reductase (enzyme that release NO from nitrates) is principally present at these sites. These agents are smooth muscle relaxants and can be used in colic and achlasia cardia Refer kDT 6/e p523

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