Pathology Systemic Pathology a81fd5a0

Not a feature of Minimal change disease:

Good response to steroids

Effacement of podocytes on electron microscope, normal on light microscope

Nil deposit disease

NSAIDS is the primary cause

High-Yield Explanation

Minimal Change Disease M/c cause of development of nephrotic syndrome in child (2-6 yrs) Primary cause (idiopathic, most common) Secondary cause (NSAIDS/Hodgkin's lymphoma/ atopy) Selective proteinuria C/F Excessive frothiness of urine Facial edema No role of immune complexes Good response to steroids

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