Microbiology General a7e07cfd The HIV virus binds directly to the surface receptors of CD4 lymphocytes with _____. A Reverse transcriptase B Integrase C Hemagglutinin D Glycoprotein 120 High-Yield Explanation HIV’s envelope contains two glycoproteins, gp120 and gp41. gp120 binds specifically with CD4 surface receptors.