Aplastic anemia can progress to -a) AMLb) Myelodysplastic anemiac) Pure red cell aplasiad) Paroxysmal nocturnal hemoglobinuriae) Myelofibrosis

Aplastic anemia is a pancytopenia with bone marrow hypocellularity. It can progress to – Paroxysmal Nocturnal hemoglobinuria Myelodysplastic anemia Rarely acute leukemia Pure red cell aplasia is a selective disease of absence of erythrocyte progenitor cells. In contrast to aplastic anemia and MDS, the unaffected lineage (WBC and platelets) appear quantitatively and qualitatively normal. Myelofibrosis is a clonal disorder of a multipotent hematopoietic progenitor cell of unknown origin and is characterized by Marrow fibrosis Myeloid metaplasia with extramedullary erythropoiesis Splenomegaly