The most appropriate management for maintaining patency of ductus aeriosus in a neonate is -

Ans. is 'a' i.e., Prostaglandin E1 o Ductus aeriosus remains patent in the uterus in the fetal life because of high level of vasodilators especially prostaglandin E, in the blood. o After bih the prostaglandin synthesis is inhibited by inhibition of cycloxygenase at bih. o So if the patency of ductus aeriosus has to be maintained --> prostaglandins should be given. o The drug which is specifically used for this is prostaglandin E, (Misoprost, Rioprostil) o If the ductus aeriousus has to be closed, prostaglandin synthesis inhibitor - Indomethacin should be given.