What is function of Intrinsic Factor - (NEET/DNB

Ans. is 'a' i.e., Increases cobalamin absorption o Intrinsic factor is a small glycoprotein secreted by the parietal cells of the gastric mucosa.lt is essential for vitamin B12 absorption.o Gastric acid and pepsin release the vitamin from protein binding in food and make it available to bind to cobalophilin, a binding protein secreted in the saliva.o In the duodenum, cobalophilin is hydrolyzed, releasing the vitamin for binding to intrinsic factor,o Intrinsic factor binds only the active vitamin Bi: vitamers and not other corrinoids.o Vitamin Bn is absorbed from the distal third of the ileum via receptors that bind the intrinsic factor vitamin B12 complex, but not free intrinsic factor or free vitamin,o Vitamin Bi; is also called as ''extrinsic factor of castle".