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Pathology General a682f2b6

Gastric carcinoma is associated with all of the following, except?

A
Inactivation of p53
B
Over expression of C-erb
C
Over expression of C-met
D
Activation of RAS
High-Yield Explanation
Mutated p53 isoforms can generate an autoimmune response. Serum anti-p53 antibodies can serve as a diagnostic and prognostic marker in gastric cancer patients.Amplification of the c-met gene has been demonstrated in scirrhous-type gastric cancers. c-met is overexpressed or amplified in advanced gastric cancers of both the well-differentiated and poorly differentiated types.Ras activation is associated with the development of gastric cancer, but it is rare.

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