Gluten-sensitive enteropathy is most strongly associated with –

Almost all individuals with celiac disease share the major histocompatibility complex II HLA-DQ2 or HLA-DQ8. Gliadin is deamidated by the enzyme transglutaminase and deamidated gliadin peptides bind to DQ2 and DQ8. Recognition of these peptides by CD4+ T cells leads to secretion of IFN-γ, which damages the intestinal wall.