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Pharmacology Anaesthesia a594fbe0

Muscle relaxant of choice in liver disease is?

A
Atracurium
B
Pipecuronium
C
Rocuronium
D
Vecuronium
High-Yield Explanation
Ans. (A) Atracurium(Ref: Katzung 11th/e p456, KDT 8th/e p.380)Atracurium and cis-atracurium are degraded spontaneously by Hoffman's elimination. These do not require liver or kidney for elimination and thus are muscle relaxant of choice in a patient with renal and hepatic dysfunction.Other drugs mentioned in the question are metabolized by liver and thus should be avoided in hepatic failure.

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