Neurotoxicity is seen with excess of

Neurotoxicity is seen with excess of Vit B6. Toxicity of pyridoxine: Pyridoxine is the only water-soluble vitamin with significant toxicity. Neurologic symptoms (sensory neuropathy) occur at intakes above 200 mg/day, an amount more than 100 times the RDA. Substantial improvement, but not complete recovery, occurs when the vitamin is discontinued. Reference: Lippincott Textbook of Biochemistry pg no. 378