Amino acid linking Kreb's cycle & urea cycle:-

Urea cycle andTCA Cycle is linked by three way Fumarate in urea cycle is the most impoant integrating point with TCA cycle. Fumarate is conveed to malate and then to oxaloacetate in TCA cycle. Oxaloacetate undergoes transamination to produce aspaate which enters urea cycle. However, Fumarate is not an amino acid so amino acid linking Kreb's cycle and Urea cycle is aspaate. Fig- Kreb's Bicycle Extra information: 12 ATPs are generated in the TCA cycle while 4 ATPs are utilized for UREA CYCLE. The CO2 liberated in the TCA cycle (in the mitochondria) can be utilized in the urea cycle