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Pathology miscellaneous a4a002e4

Leucocyte ALP>13 is seen in all except -

A
Chronic myeloid leukaemia
B
Leukemoid reaction
C
Pregnancy
D
Inflammatory conditions
High-Yield Explanation
Leukocyte alkaline phosphatase (LAP) is found within mature WBC. White blood cell levels of LAP can help in the diagnosis of ceain conditions. Higher levels are seen in the physiological response, the leukemoid reaction, and in pathologies that include mature white blood cells, such as polycythemia vera (PV), essential thrombocytosis(ET), and in primary myelofibrosis (PM). Lower levels are found in pathologies that involve undeveloped leukocytes, such as chronic myelogenous leukemia (CML), paroxysmal nocturnal hemoglobinuria (PNH) and acute myelogenous leukemia (AML).

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