Transplantation of liver is contraindicated in
High-Yield Explanation
Contraindications to Liver Transplantation Absolute Relative Uncontrolled extrahepatobiliary infection Active, untreated sepsis Incorrect able, life-limiting congenital anomalies Active substance or alcohol abuse Advanced cardiopulmonary disease Extrahepatobiliary malignany (not including nonmelanoma skin cancer) Metastatic malignancy to the liver Cholangiocarcinoma AIDS Life-threatening systemic diseases Age >70 years Prior extensive hepatobiliary surgery Poal vein thrombosis Renal failure not attributable to liver disease Previous extrahepatic malignancy( not including nonmelanoma akin cancer) Severe Obesity Severe malnutrition/wasting Medical noncompliance HIV seropositivity with failure to control HIV viraemis or CD4 <100/uL Intrahepatic sepsis Severe hypoxemia secondary to right - to-left intrapulmonary shunts (Po2<50mmHg) Severe pulmonary hypeension(mean pulmonary aery pressure >35 mmHg) Uncontrolled psychiatric disorder Ref: Sabiston 20th edition Pgno : 637-638