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Pathology General a405cf1a

Amplification of N-Myc is associated with which a tumor?

A
Neuroblastoma
B
Retinoblastoma
C
Osteosarcoma
D
Neuroma
High-Yield Explanation
Amplification of N-Myc is associated with a variety of tumors, most notably neuroblastomas. This gene is a member of the MYC family of transcription factors and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA.

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