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Pathology General a3cac66c

Characteristic histopathology finding in Whipples disease is ?

A
PAS positive macrophages and rod shaped bacilli in lamina propria
B
Shoened thickened villi with increased crypt depth
C
Blunting and flattening of mucosal surface and absent villi
D
Mononuclear infiltration at base of crypts
High-Yield Explanation
Ans. is 'a' i.e., PAS positive macrophages and rod shaped bacilli in lamina propriaThe hallmark of Whipple's disease is a small intestinal mucosa laden with distended macrophages in the lamina propria- the macrophages contain periodic acid-schiff (PAS) positive granules and rod shaped bacilli by electron microscopy.Three forms of Malabsorption Syndromes are often asked and the basic understanding of these is able to exclude a large number of questions.

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