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Biochemistry General a3c3ec67

Which one of the following coenzyme is associated with glycogen phosphorylase?

A
Thiamine pyrophosphate
B
Tetrahydrofolate
C
Flavin mononuleotide
D
Pyridoxal phosphate
High-Yield Explanation
Glycogen phosphorylase has a pyridoxal phosphate (PLP, derived from Vitamin B6) at each catalytic site. Pyridoxal phosphate links with basic residues and covalently forms a Schiff base. Once the Schiff base linkage is formed, holding the PLP molecule in the active site, the phosphate group on the PLP readily donates a proton to an inorganic phosphate molecule, allowing the inorganic phosphate to in turn be deprotonated by the oxygen forming the a-1,4 glycosidic linkage.

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