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Gynaecology & Obstetrics Congenital malformations a38bf6c1

All of the following take pa in male genital tract development except;

A
SRY
B
SOX-9
C
FGF-9
D
WNT4
High-Yield Explanation
SRY is a transcription factor and master gene for testes development.It appears to act in conjuction with autosomal gene SOX-9,transcriptional regulator that can induce testis differentiation.SOX-9 binds to promotor region of gene for AMH substance and regulates its expression.They both induce secretion of FGF-9 that act as a chemotactic factor that make tubules from mesonephric duct to penetrate gonadal ridge.SRY directly or indirectly upregulates steroidogenesis factorwhich differentiates leydig and seoli cells. LANGMAN&;S MEDICAL EMBRYOLOGY,12 TH EDITION ,Pg no:246

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