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Gynaecology & Obstetrics General a371af3f

Following can cause endometrial cancer:

A
Metropathia hemorrhagica
B
Gynandroblastoma
C
Dysgerminoma
D
All of the above
High-Yield Explanation
Endometrial cancer is mainly caused by excessive estrogen Metropathia hemorrhagica is the same as cystic glandular hyperplasia and is a causative factor for endometrial cancer. Ref Dutta Gynae 5th /ed p 184 Gynandroblastoma is a virilising tumor which secretes androgens (not estrogens) and so does not lead to endometrial cancer  Ref. Shaw 14th /ed p 34 Dysgerminoma is a neutral tumor which does not secrete either male or female sex hormones but secretes placental alkaline phosphates, LDH and BHCG and therefore does not lead to endometrial cancer. - Ref Shaw 14th /ed 3386

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