Mediator of acute inflammation not derived from the cell is (D. REPEAT Feb 2014)

Chemical Mediators of Inflammation Aka permeability factors or endogenous mediators of increased vascular permeability. They are broadly classified into 2 groups: i. Mediators released by cells. ii. Mediators originating from plasma. Chemical Mediators of Acute Inflammation A. Cell-Derived Mediators 1. Vasoactive amines Histamine 5-hydroxytryptamine Neuropeptides 2. Arachidonic acid metabolites (Eicosanoids) i. Metabolites via cyclo-oxygenase pathway Prostaglandins Thromboxane A2 Prostacyclin Resolvins ii. Metabolites via lipo-oxygenase pathway 5-HETE Leukotrienes Lipoxins 3. Lysosomal components (from PM Ns, macrophages) 4. Platelet-activating factor (PAF) 5. Cytokines IL-1 TNF-α TNF-β IFN-γ Chemokines 6. Free radicals Oxygen metabolites Nitric oxide B. Plasma-Derived Mediators (Plasma Proteases) Products of: 1. The Kinin system. 2. The Clotting system. 3. The Fibrinolytic system. 4. The Complement system.