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Pediatrics JIPMER 2017 a2ff4e81

A 6 - year - old boy with lymphoreticular malignancy has come for a cycle of chemotherapy. Which of the following investigatins need to be done for next 4 hours to diagnose tumour lysis syndrome?

A
Urea, creatinine, chloride, Ca2+ and K+
B
Urea, creatinine, phosphate, Ca2+ and K+
C
Urea, creatinine, magnesium, Ca2+ and K+
D
Urea, creatinine, sodium and phosphate
High-Yield Explanation
Tumour lysis syndrome (TLS) - -Uric acid, phosphate and potassium are released in large quantities from death of tumour cells. -Hyperuricemia can lead to impairment of renal function, which fuher exacerbates the metabolic abnormalities. -Hypocalcaemia is a consequence of acute hyperphosphatemia with subsequent precipitation of calcium phosphate in soft tissues. 'TLS can occur before therapy in patients with a large tumour burden (e.g., Burkitt lymphoma, Hyperleukocytosis) It is usually seen within 12-48 hr of initiating chemotherapy.

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