HC1 secretion in gastric phase is increase by

Acid in the antrum inhibits gastrin secretion, paly by a direct action on G cells and paly by release of somatostatin, a relatively potent inhibitor of gastrin secretion. Th effect of acid is the basis of a negative feedback loop regulating gastrin secretion. Increased secretion of the hormone increases acid secretion, but the acid then feeds back to inhibit fuher gastrin secretion. REFERENNCE ; GANONGS REVIEW OF MEDICAL PHYSIOLOGY 24TH EDITION