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Pharmacology Hematology a23293ff

True about oral anticoagulant warfarin are all EXCEPT:

A
Acts in vivo
B
Acts both in vivo and in vitro
C
Interferes with synthesis of Vit K
D
Causes Hematuria
High-Yield Explanation
* Oral anticoagulant is warfarin. It is used only in vivo (body), not in vitro (lab).* Warfarin is not used to store blood.* It acts by inhibiting Vitamin K. Due to overdose, hematuria is the first manifestation noted.* Dose monitoring is done by INR.* Antidote of warfarin overdose: Vitamin KPT (Prothrombin Time)aPTT (activated Partial Thromboplastin Time)Assess activity of Extrinsic coagulation pathway Used when on warfarin treatmentWePT: Warfarin for extrinsic; PT value assessed.Assess activity of Extrinsic coagulation pathway.Used while on heparin treatment.HINT: Heparin for Intrinsic; aPTT value assessed.

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