AST/ALT > 2 is seen in deficiency of

The AST/ALT ratio is the ratio between the concentrations of the enzymes aspaate transaminase (AST) and alanine transaminase, aka alanine aminotransferase (ALT) in the blood of a human or animal. It is measured with a blood test and is sometimes useful in medical diagnosis to differentiate between causes of liver damage, or hepatotoxicity. the following are typical AST and ALT patterns relating to the "upper limit of normal" (ULN) Alcoholic fatty liver disease: AST > 8 times the ULN; ALT > 5 times the ULN Nonalcoholic fatty liver disease: AST and ALT > 4 times the ULN Acute viral hepatitis or toxin-related hepatitis with jaundice: AST and ALT > 25 times the ULN Ischemic hepatopathy (ischemic hepatitis, shock liver): AST and ALT > 50 times the ULN (in addition the lactate dehydrogenase is often markedly elevated) Chronic hepatitis C virus infection: Wide variability, typically normal to less than twice the ULN, rarely more than 10 times the ULN Chronic hepatitis B virus infection: Levels fluctuate; the AST and ALT may be normal, though most patients have mild to moderate elevations (approximately twice the ULN); with exacerbations, levels are more than 10 times the ULN Acid maltase deficiency (AMD) is an autosomal recessive disease characterized by an excessive accumulation of glycogen within lysosome-derived vacuoles in nearly all types of cells.