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Pharmacology Other topics and Adverse effects a16dee33

Methicillin resistant staphylococci do not respond to b-lactam antibiotics because:

A
They produce a b-lactamase which destroys methicillin and related drugs
B
They elaborate an amidase which destroys methicillin and related drugs
C
They have acquired penicillin binding protein which has low affinity for b-lactam antibiotics
D
They are less permeable to b-lactam antibiotics
High-Yield Explanation
(Ref: KDT 6/e p700) Resistance to most penicillins is due to elaboration of beta-lactamase. Methicillin is most resistant penicilling to b-lactamase. Staphylococcus aureus develops resistance to methicillins by acquisition of altered pencillin binding proteins.
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