True about methicillin-resistant staphylococcus aureus (MRSA) -a) Isoxazolyl penicillin is highly effectiveb) All MRSA are multidrug resistantc) Vancomyin is effectived) MRSA are more virulent than sensitive strainse) Resistance develop due to altered binding protein

Methicillin resistance staphyloccus aureus (MRSA) MRSA is a bacterium responsible for several difficult to treat infections in humans. It may also be referred to as multidrug resistant staphyloccus aureus or oxacillin resistant staphylococcus aureus (ORSA) MRSA is by definition any strain of staphyloccus aureus that is resistant to a β-lactams (including penicillin, methicillin, cloxacillin, nafcillin and oxacillin, cephalosporin). Resistance develops due to alteration in transpeptidase (penicillin binding protein) on which all β-lactam antibiotic act → So, MRSA is resistant to all β-lactam antibiotics. MRSA (especially community acquired MRSA; CA-MRSA) display enhanced virulence, spreading more rapidly and causing disease much more severe than traditional staphylocccus aureus. Vancomycin is the DOC for MRSA.