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Pharmacology General a03be6cd

Mechanism of action of dantroline is ?

A
Inhibits Ca++ secretion from sarcoplasm
B
Binds to ryanodine receptors to block release of Ca++
C
Inhibits GABA
D
Inhibits Gamma motor neuron
High-Yield Explanation
Ans. is 'b' i.e., Binds to ryanodine receptors to block release of Ca++ o Dantrolone acts on Ryanodine receptors (RyR) Calcium channels in sarcoplasmic reticulum of skeletal muscles and prevents their depolarization triggered opening --> no release of intracellular Ca-+2 --> No excitation contraction coupling --> No contraction.

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