An alpha helix of a protein is most likely to be disrupted if a missense mutation introduces the following amino acid within the alpha helical structure:

* The alpha helix is disrupted by introduction of following amino acids. 1. Proline - Most common 2. Charged amino acids like H - Histidine A - Aspaic acid A - arginine G - Glutamic acid Ly-Iysine 3. Amino acids with bulky side chains if present in large number eg - (a) Tryptophan (b) Valine (c) Isoleucine