Regarding Analgesic Nephropathy which of the following is TRUE/FALSE? 1. Small, scarred kidneys with papillary calcifications are a feature. 2. Patients usually have anuria due to papillary necrosis. 3. Individuals with analgesic nephropathy are at increased risk of a urothelial malignancy. 4. Heavy users of acetaminophen should be screened for evidence of renal disease. 5. Non-anion-gap metabolic acidosis from tubular damage is seen in analgesic nephropathy.

Analgesic nephropathy patients will have small, scarred kidneys with papillary calcifications best appreciated by computed tomography. Patients may also have polyuria due to impaired concentrating ability and non-anion-gap metabolic acidosis from tubular damage. Individuals with end-stage kidney disease as a result of analgesic nephropathy are at increased risk of a urothelial malignancy it is recommended that heavy users of acetaminophen and NSAIDs be screened for evidence of renal disease. Ref: Harrisons Principles of Internal Medicine, 18th Edition, Page 2372