Lymph node biopsy of an AIDS patient shows: March 2009

Ans. D: All of the above Histopathology of HIV Florid reactive hyperplasia-may be: - Collections of monocytoid B cells in sinuses - Neutrophils - Features of dermatopathic lymphadenopathy Often reactive germinal centers show 'follicle lysis':i.e. invagination of mantle lymphocytes into germinal centers associated with: - Disruption of centers ('moth-eaten appearance') - Distinctive clustering of large follicular center cells resulting appearance termed explosive follicular hyperplasia Occasional polykaryocytes: - Wahin-Finkeldey cells - May be multinucleated form of follicular dendritic cell Electron microscopy: - Sometimes prominent follicular dendritic cells exhibit alterations of their fine processes Interfollicular tissue may show prominent vascular proliferation: vague resemblance to Castleman's disease - These areas and subcapsular region may reveal earliest signs of Kaposi's sarcoma - Sometimes advanced lymphocyte depletion: may be abnormal (regressively transformed) germinal centers