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Unknown General 9f42840c

Which of the following is false regarding TRALI?

A
Due to release of mediators from the neutrophils in the lungs
B
Occurs within 6 hours of tramsfusion
C
Occurs more common when the donor is a multiparous lady
D
All of the above
High-Yield Explanation
Ref. Robbins Pathology. 9th edition. Page. 666 TRALI: Transfusion-Related Acute Lung Injury (TRALI) is a syndrome characterized by acute respiratory distress following transfusion. All plasma-containing blood products have been implicated including rare reports of IVIG and cryoprecipitate It is a rare complication of allogeneic blood transfusion Two theories on the pathogenesis of TRALI have been proposed Antibodies to white blood cell antigens (HLA, granulocyte and monocyte) Clinical condition of the patient (e.g. sepsis, trauma, etc) which causes sequestration of primed neutrophils in the activated pulmonary endothelium

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