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Pathology General 9f158858

All of the following statements regarding apoptosis are TRUE, EXCEPT:

A
Considerable apoptosis may occur in tissues before it becomes apparent in histology
B
Apoptotic cells appear round mass of the intensely eosinophilic cytoplasm with dense nuclear chromatin fragments
C
Apoptosis of cells induce inflammatory reaction
D
Macrophages phagocytose the apoptotic cells and degrade them.
High-Yield Explanation
Apoptosis refers to preprogrammed natural or physiological cell death. It occurs without any inflammatory reaction. Features of apoptosis are: Death occur by shrinkage It affects isolated cells It is a gene initiated process, and DNA fragments are small and regular Histologic features: Cell shrinkage Nuclear condensation and fragmentation Membrane budding Buds includes cell organelles Buds detach to form apoptotic bodies Phagocytosis of the apoptotic bodies occur Ref: Textbook of Pathology By Datta page 48.

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