Leber's amourotic optic neuropathy inheritance is

Ans. a. Mutation in mitochondrial DNALeber hereditary optic neuropathy (LHON) is rare ganglion cell degeneration.Papillomacular bundle is particularly affected in this case.The condition is caused by maternally inherited mitochondrial DNA point mutations, most frequently (50-90%) at nucleotide position 1178 (G to A) in theMT-ND4 gene.Most commonly affects age group 15-35 years.