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Pharmacokinetic characteristics of propranolol include Vd = 300 L/70 kg, C1 = 700 mL/min, and oral bioavailability f = 0.25. What is the dose needed to achieve a plasma level equivalent to a steady state level of 20 mg/L?

A

4 mg

B

12 mg

C

24 mg

D

48 mg

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