Which of the following agents should not be used for oral anticoagulation in high risk patients with atrial fibrillation
High-Yield Explanation
Oral anticoagulation in high-risk patients with AF includes vitamin K antagonists or the newer anticoagulants such as thrombin inhibi- tors (dabigatran) or factor Xa inhibitors (rivaroxaban, apixaban), but not antiplatelet agents (aspirin and clopidogrel), which have substantially less effect. Ref Harrison 20th edition pg 1456