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Pediatrics General 9e2abbad

Causes of female pseudohermaphroditism –

A
17–alpha hydroxylase deficiency
B
21–alpha hydroxylase deficiency
C
Mixed gonadal dysgenesis
D
All of the above
High-Yield Explanation
Ambiguous genitalia (Hermaphroditism) Ambiguous genitalia is defined as a discrepancy between the external genitals and internal gonads. They can be categorized : - Female pseudohermaphroditism Male pseudohermaphroditism True hermaphroditism Female pseudohermaphroditism. Genotype is XX Gonads are ovaries External genitalia is virilized (male differentiation). As there is no Mullarian inhibiting factor, Mullerian duct develops into uterus tubes and ovary. But due to the presence of androgen external genitalia are virilized. Causes are: Maternal virilizing tumour → Arrhenoblastoma 21 hydroxylase deficiency 11 beta hydroxylase deficiency Maternal medications with androgen

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