Hereditary spherocytosis is due to deficiency of:September 2007

Ans. A: SpectrinHereditary spherocytosis (HS) is due to a deficiency of a protein called ankyrin.Ankyrins are cell membrane proteins (thought to interconnect integral proteins with the spectrin-based membrane skeleton)The ankyrin of red blood cells (erythrocytic ankyrin) is called ankyrin-R/ankyrin-1/ ANK1.