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Pharmacology DNB 2018 9dbf19e1

Which of the following drug predominantly act by decreasing the preload of hea?

A
Calcium channel blockers
B
Minoxidil
C
Hydralazine
D
Nitroglycerine
High-Yield Explanation
Vasodilator: Nitrate: |Preload Aeria dilator: Hydralazine:|Afterload Mixed - Nitroprusside ACE(-) | Both Preload and afterload ARBS - Minoxidil : Pottasium channel opener, enhance potassium efflux causing membrane hyperpolarization leading to decrease in calcium entry and smooth muscle relaxation causing vasodilation. Minoxidil and finasteride are trichogenic agents that are indicated for the treatment of androgenic alopecia ("male pattern baldness"). Minoxidil, originally used as a systemic antihypeensive, was noted to have the adverse effect of increased hair growth.

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