Second primary malignancy of head and neck is commonly associated with which of the following

Ans. a. Oral cavity Second primary malignancy of head and neck is commonly associated with oral cavity. "The site of index cancer influences the most likely site of a second primary malignancy, as an example, in a series of 1257 patients with SCC of the head and neck, patients with an index malignancy arising in the larynx were more like to develop a second primary cancer in the lung, while those arising in the oral cavity were more likely to develop a second primary in the head and neck or esophagus. This relationship has been observed in other studies as well."- Second primary malignancies in patients with head and neck cancers by Sandeep Samant, Head and Neck 2005; 27; 1042 Patients with head and neck SCC are at increased risk for the development of second primary malignancies compared with general populationQ. These second primary malignancies typically develop in the aerodigestive tract (lung, head and neck, esophagus)Q. MC second primary malignancy: Lung cancerQ Highest relative increase in risk is for a second head and neck cancerQ