Non-immune hemolytic anemia occurs in -

Non-Immune hemolytic anemia In non-immune hemolytic anemia, hemolysis occurs without formation of antibodies against RBCs. Combs test is negative, therefore it is also known as Coombs negative hemolytic anemia. Causes are : - Drugs Ribavirin Toxins → Snake venum, plant poisons such as aesculin. Mechanical trauma to RBCs → prosthetic heart valve, thrombosis in microcirculation. Microangiopathic hemolytic anemia :- Thrombotic thrombocytopenia purpura (TTP), Hemolytic uremic syndrome (HUS), DIC, HELLP syndrome. Infections : - Babesiosis, Malaria, Clostridium perfringens sepsis. Hereditary spherocytosis, Thalassemia, SCA, Paroxysmal nocturnal hemoglobinuria, Liver disease.