In the apoptosis,Apaf-1 is activated by release of which of the following substances from the mitochondria

Ref, Harrison 17/e p506,9/ep55 Apoptosis or programmed cell death can be induced by intrinsic or extrinsic pathway.as can be seen in the intrinsic pathway;cytc gets associatio with ApAF-1 which activates caspases and causes cell death