A patient with chronic kidney disease on dialysis is posted for emergency laparotomy. Which of the following anaesthetic agent is contraindicated in this patient?
High-Yield Explanation
Gallamine is one of a series of synthetic substitutes for curare. Gallamine has the most potent vagolytic propeies of any relaxant, and it is entirely dependent on renal function for elimination. In renal insufficiency the neuromuscular blockade that it causes is considerably prolonged and gallamine is contraindicated. Ref: Butterwoh IV J.F., Butterwoh IV J.F., Mackey D.C., Wasnick J.D., Mackey D.C., Wasnick J.D. (2013). Chapter 11. Neuromuscular Blocking Agents. In J.F. Butterwoh IV, J.F. Butterwoh IV, D.C. Mackey, J.D. Wasnick, D.C. Mackey, J.D. Wasnick (Eds), Morgan & Mikhail's Clinical Anesthesiology, 5e.